# Foundayo™ (Orforglipron) — Imbue Health

> Last updated: 2026-05-27 · Source of truth: https://tryimbue.com/medications/foundayo
> Medically reviewed by the Imbue Health Medical Team

## At a glance

| | |
|---|---|
| **Brand name** | Foundayo™ |
| **Generic / active ingredient** | Orforglipron (GLP-1 receptor agonist; non-peptide small molecule) |
| **Manufacturer** | Eli Lilly |
| **Fulfilment** | LillyDirect (manufacturer pharmacy) |
| **Format** | Once-daily oral pill — **any time of day, no food or water restrictions** |
| **Cash-pay medication price** | **$149–$299 / month** (by dose) |
| **Total monthly cost on Imbue Health** | **$178–$328 / month** ($29 membership + $149–$299 medication, by dose) |
| **Average weight loss** | 12.4% body weight at 72 weeks (ATTAIN-1 trial, highest dose) |
| **FDA indication** | Chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥25) with at least one weight-related condition |

### Cash-pay price by dose (Foundayo™)

| Dose | Cash-pay price / month |
|---|---|
| 0.8 mg | $149 |
| 2.5 mg | $199 |
| 5.5 mg | $299 |
| 9 mg | $299 |
| 14.5 mg | $299 ($349 if not refilled within 45 days) |
| 17.2 mg | $299 ($349 if not refilled within 45 days) |

Plus a flat $29/month Imbue Health membership. Prices are set by the manufacturer (LillyDirect).

## What makes Foundayo™ unique

Foundayo™ is the **only FDA-approved GLP-1 pill with no food or water restrictions**. Take it any time of day, with or without food, with any beverage. Other GLP-1 pills (e.g., Oral Wegovy®) require a strict empty-stomach protocol with ≤120 mL water and a 30-minute fast.

This is possible because orforglipron is a **non-peptide small molecule**. Traditional GLP-1s (semaglutide, tirzepatide) are peptides — large, fragile molecules that are destroyed by stomach acid unless protected by special formulations. Orforglipron's small-molecule structure survives normal digestion, so the strict empty-stomach protocol isn't needed.

## How it works

Orforglipron activates the GLP-1 receptor through "biased agonism" — favouring sustained signalling for effective once-daily dosing. The receptor activation:

- Suppresses appetite via central pathways in the hypothalamus
- Slows gastric emptying so you feel fuller longer
- Enhances glucose-dependent insulin secretion
- Reduces "food noise" / preoccupation with food (commonly reported by patients)

## Clinical results

| Trial | Patients | Result |
|---|---|---|
| **ATTAIN-1** (Phase 3, Eli Lilly) | Adults with obesity/overweight + ≥1 weight-related condition | 12.4% average body-weight loss at 72 weeks (highest dose) |
| **ATTAIN-1** | Same | 59.6% of patients achieved ≥10% weight loss |
| **ATTAIN-MAINTAIN** | Patients switching from injectable GLP-1 to Foundayo™ | Maintained previously achieved weight loss |

## Eligibility

- Adults 18+ in all 50 U.S. states and Washington, D.C.
- BMI ≥30, **or** BMI ≥25 with at least one weight-related condition.
- BMI 25–26.9 is below FDA label and prescribed at provider discretion.
- No personal or family history of medullary thyroid carcinoma or MEN 2 syndrome.

## Side effects

Most common (typically resolve in 2–4 weeks as your body adjusts):

- Nausea, vomiting, diarrhoea, constipation
- Decreased appetite
- Fatigue
- Headache

Boxed warning: thyroid C-cell tumors (medullary thyroid carcinoma) — your Imbue Health physician screens for personal/family history before prescribing.

Other serious risks: pancreatitis, gallbladder disease, severe GI symptoms, kidney problems. Report any of these immediately.

For complete safety information, visit https://tryimbue.com/safety.

## How to get Foundayo™ through Imbue Health

1. Complete the 5-minute health assessment at https://tryimbue.com (or https://app.tryimbue.com/get-started).
2. Get evaluated by a licensed, board-certified Imbue Health physician.
3. If prescribed, pay $29/mo for Imbue Health membership.
4. LillyDirect ships Foundayo™ to your door at $149–$299/month cash-pay (by dose).

Total: $178–$328/month (by dose). No insurance billed, no contracts, cancel anytime.

## Refund policy

If our physician determines Foundayo™ isn't right for you based on your health profile, **you won't be charged the $29 membership fee**. You're never charged before a prescribing decision.

## FAQ

**Why is Foundayo™ cheaper than Zepbound®?**
Foundayo™ and Zepbound® are both made by Eli Lilly, but Eli Lilly sets a lower published self-pay price for Foundayo™ ($149–$299/mo by dose) than for Zepbound® ($299–$449/mo by dose). This reflects Lilly's positioning, not relative effectiveness — Zepbound® has higher average weight loss (22% vs 12.4%) but Foundayo™ offers the convenience of a daily pill.

**Can I switch from injectable Wegovy® or Zepbound® to Foundayo™?**
Yes. The ATTAIN-MAINTAIN trial showed that patients switching from injectable Wegovy® or Zepbound® to Foundayo™ maintained their previously achieved weight loss. Your Imbue Health physician manages the transition.

**Does Foundayo™ have the same cardiovascular benefit as Wegovy®?**
Cardiovascular outcomes are still being studied for orforglipron. As of 2026, Wegovy® has the strongest cardiovascular evidence (20% reduction in major cardiovascular events in SELECT trial). If cardiovascular protection is your primary goal, discuss Wegovy® with your physician.

**Do I need to take Foundayo™ at the same time every day?**
Once-daily, but timing is flexible. Pick a time that works for your routine — Foundayo™ doesn't require fasting before or after.

## Related

- Foundayo™ cost detail: https://tryimbue.com/foundayo-cost
- Oral vs injectable GLP-1 comparison: https://tryimbue.com/learn/oral-vs-injectable-glp1
- Full GLP-1 guide: https://tryimbue.com/learn/glp1-guide
- Compare medications on Imbue Health: https://tryimbue.com/medications

## About

Operating entity: Cyane Inc. Medical practice: Cyane Medical Group California PC. Medical Director: Dr. Prajeet Reddy, MD. LegitScript Healthcare Merchant Certified. HIPAA-compliant.

Address: 169 Madison Ave Ste 11456, New York, NY 10016 · Phone: +1-855-695-4959 · Email: support@tryimbue.com