# Wegovy® (Semaglutide Injection) — Imbue Health

> Last updated: 2026-05-27 · Source of truth: https://tryimbue.com/medications/wegovy
> Medically reviewed by the Imbue Health Medical Team

## At a glance

| | |
|---|---|
| **Brand name** | Wegovy® |
| **Generic / active ingredient** | Semaglutide (GLP-1 receptor agonist) |
| **Manufacturer** | Novo Nordisk |
| **Fulfilment** | NovoCare (manufacturer pharmacy) |
| **Format** | Once-weekly subcutaneous injection (pre-filled pen) |
| **Cash-pay medication price** | **$199 / month (intro) · $349 / month standard · $399 / month (7.2 mg HD pen)** |
| **Total monthly cost on Imbue Health** | **$228 / month (intro) · $378–$428 / month standard (by dose)** |
| **Average weight loss** | 15% body weight at 68 weeks (STEP 1 trial) |
| **Cardiovascular benefit** | 20% reduction in major cardiovascular events (SELECT trial) — for adults with obesity and established heart disease |
| **FDA indication** | Chronic weight management in adults with obesity (BMI ≥30) or overweight (BMI ≥25) with at least one weight-related condition |

## What makes Wegovy® unique

Wegovy® is the **standard of care for chronic weight management**. It has the longest clinical track record of any GLP-1 approved for weight loss, the strongest cardiovascular outcomes data, and broad familiarity among clinicians.

The SELECT trial (2023) demonstrated that semaglutide reduced major cardiovascular events by 20% in adults with obesity and pre-existing cardiovascular disease — a result that fundamentally changed how obesity medications are positioned in cardiovascular medicine.

## How to take it

Wegovy® is a **once-weekly subcutaneous injection** delivered by a pre-filled pen. Dose escalation follows a standard titration:

- Week 1–4: 0.25 mg
- Week 5–8: 0.5 mg
- Week 9–12: 1 mg
- Week 13–16: 1.7 mg
- Week 17+: 2.4 mg (maintenance)

Inject into thigh, abdomen, or upper arm. Rotate sites. Store in the refrigerator until use.

## Clinical results

| Trial | Patients | Result |
|---|---|---|
| **STEP 1** (Novo Nordisk) | Adults with obesity, 68-week treatment | 14.9% average body-weight loss |
| **STEP 4** | Same | 85% maintained weight loss at 2 years |
| **STEP 5** | Long-term extension | Sustained weight loss at 4 years |
| **SELECT** | Adults with obesity + established cardiovascular disease | 20% reduction in major cardiovascular events |

## Pricing structure

NovoCare offers cash-pay pricing for Wegovy® by dose, with a limited-time intro for new patients:

| Dose | Cash-pay price / month |
|---|---|
| 0.25 mg | $199 (limited-time intro — first 2 months, new patients; $349 standard) |
| 0.5 mg | $199 (limited-time intro — first 2 months, new patients; $349 standard) |
| 1 mg | $349 |
| 1.7 mg | $349 |
| 2.4 mg | $349 |
| 7.2 mg (HD pen) | $399 |

Combined with Imbue Health's flat $29/mo membership, total monthly cost is **$228/month (intro)**, up to **$378–$428/month** (standard, by dose).

## Side effects

Most common (typically resolve in 2–4 weeks):

- Nausea, vomiting, diarrhoea, constipation
- Decreased appetite
- Headache, fatigue
- Injection-site reactions

Boxed warning: thyroid C-cell tumors. Other serious risks: pancreatitis, gallbladder disease, severe GI symptoms, kidney problems, diabetic retinopathy worsening. See https://tryimbue.com/safety.

## Eligibility

- Adults 18+ in all 50 U.S. states and Washington, D.C.
- BMI ≥30, **or** BMI ≥25 with at least one weight-related condition.
- BMI 25–26.9 is below FDA label and prescribed at provider discretion.
- No personal or family history of medullary thyroid carcinoma or MEN 2 syndrome.

## How to get Wegovy® through Imbue Health

1. 5-minute health assessment at https://tryimbue.com.
2. Licensed Imbue Health physician evaluation.
3. $29/mo Imbue Health membership.
4. NovoCare ships Wegovy® with cold-chain packaging — $199/mo intro, $349–$399/mo standard (incl. 7.2 mg HD pen).

**Total: $228/mo (intro), $378–$428/mo standard (by dose).** Imbue Health is a cash-pay program — we do not accept insurance.

## Refund policy

If our physician determines Wegovy® isn't right for you, you won't be charged the $29 membership fee.

## FAQ

**Why is Wegovy® more expensive than Foundayo™ or Oral Wegovy®?**
Novo Nordisk sets a higher cash-pay rate for injectable Wegovy® ($199 intro / $349–$399 standard) than for Oral Wegovy® ($149–$299 by dose). The pricing reflects the manufacturer's positioning, not relative efficacy.

**Wegovy® vs Zepbound® — which is better for weight loss?**
In the SURMOUNT-5 head-to-head trial (NEJM 2025), Zepbound® (tirzepatide) produced 20.2% mean weight loss vs 13.7% for Wegovy® (semaglutide) over 72 weeks. Tirzepatide's dual GIP/GLP-1 mechanism drives the difference. However, Wegovy® has stronger cardiovascular outcomes evidence (SELECT trial). Choose Wegovy® if cardiovascular protection is a primary goal; choose Zepbound® for maximum weight loss.

**Can I switch from Wegovy® injection to the Oral Wegovy® pill?**
Yes. Same active ingredient (semaglutide), different format. Your Imbue Health provider manages the transition.

**What's the cheapest brand-name Wegovy® without insurance?**
Through Imbue Health: from $228/month all-in at the starting dose, up to $378/month for higher doses. Imbue Health is a cash-pay program — we do not accept insurance.

**Does Wegovy® need refrigeration?**
Yes. Store in the refrigerator (36°F – 46°F / 2°C – 8°C). NovoCare ships with cold-chain packaging. After first use, a pen can be at room temperature for up to 28 days.

## Related

- Cheapest Wegovy® overall: https://tryimbue.com/cheapest-wegovy
- Wegovy® without insurance: https://tryimbue.com/wegovy-without-insurance
- Wegovy® cost detail: https://tryimbue.com/wegovy-cost
- Compare to Zepbound®: https://tryimbue.com/medications/zepbound
- Oral vs injectable GLP-1: https://tryimbue.com/learn/oral-vs-injectable-glp1

## About

Operating entity: Cyane Inc. Medical practice: Cyane Medical Group California PC. Medical Director: Dr. Prajeet Reddy, MD. LegitScript Healthcare Merchant Certified. HIPAA-compliant.

Address: 169 Madison Ave Ste 11456, New York, NY 10016 · Phone: +1-855-695-4959 · Email: support@tryimbue.com