Zepbound® Vials
tirzepatide injection
Dual-action GIP and GLP-1 for maximum weight loss results.
Last clinically reviewed: May 13, 2026 by the Imbue Health Medical Team
22%
Avg. Weight Loss
$299–$449
Per Month (by dose)
weekly
Injection
FDA
Approved
FDA Approved
Clinically Proven
22%
Avg. Weight Loss
Cost-focused pages for Zepbound® Vials
What is Zepbound® Vials?
Zepbound® Vials is the newest FDA-approved weight loss injection, featuring a dual-action formula that activates both GIP and GLP-1 receptors. This dual mechanism has shown superior weight loss results in clinical trials.
How It Works
Tirzepatide is the first dual GIP and GLP-1 receptor agonist. By activating both hormone pathways, it provides enhanced appetite suppression, improved blood sugar control, and more significant weight loss compared to GLP-1-only medications.
Key Mechanism:
"Mimics natural hormones to reduce appetite, increase feelings of fullness after meals, and regulate metabolism."
Meet Zepbound® Vials
Once weekly
Inside the Package
4 single-use vials
Delivered via LillyDirect
Ships from Eli Lilly
Once weekly
Vial & syringe injection
Maximum Results
22% avg. weight loss
Via LillyDirect
Ships from manufacturer
Requires Refrigeration
Cold-chain shipping included
Clinical Results
average body weight loss — highest of any FDA-approved medication
Duration
72 weeks
Participants
5,000+
Key Finding:
68% of patients lost 20% or more of their body weight
Dual GLP-1/GIP mechanism provides enhanced appetite suppression
Important Note
"Results may vary. Weight loss is a journey and individual results depend on adherence to treatment, starting weight, and biological response."
Dosing Information
Designed for simplicity and effectiveness. Your provider will guide your specific dosing schedule.
Frequency
Once weekly
Instructions
Inject under the skin of your stomach, thigh, or upper arm
Titration
Start at 2.5mg, with increases every 4 weeks up to maximum 15mg
Side Effects
Common Side Effects
- Nausea
- Diarrhea
- Decreased appetite
- Vomiting
- Constipation
- Indigestion
Most side effects are mild and improve as your body adjusts to the medication.
Serious Side Effects
- Thyroid tumors (boxed warning)
- Pancreatitis
- Hypoglycemia
- Acute kidney injury
- Severe GI problems
Who Is This For?
Our medications are prescribed for individuals who meet specific medical criteria.
BMI Requirement
Adults with BMI ≥30 (obesity) or BMI ≥25 (overweight) with at least one weight-related condition.
BMI 25–26.9 is below FDA label thresholds and prescribed at the provider's discretion. BMI under 25 may be considered in cases of abnormal weight gain, at the provider's discretion.
Commitment
Individuals ready to combine medication with lifestyle changes for long-term weight success.
Best For
Patients seeking maximum weight loss results. Zepbound® is the only dual-action GLP-1/GIP medication approved for weight management, with the highest average weight loss in clinical trials (22%).
Who should NOT take this
Do not take if you have a personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or are pregnant/breastfeeding.
Simple, Transparent Pricing
Total Monthly Cost
$328–$478/month$29/mo
Every month
$299–$449/mo
Medication
Cash-pay medication price by dose
| Dose | Price / month |
|---|---|
| 2.5 mg | $299 |
| 5 mg | $399 |
| 7.5 mg | $449Self Pay Journey; regular price if not refilled within 45 days |
| 10 mg | $449Self Pay Journey; regular price if not refilled within 45 days |
| 12.5 mg | $449Self Pay Journey; regular price if not refilled within 45 days |
| 15 mg | $449Self Pay Journey; regular price if not refilled within 45 days |
Plus the flat $29/month Imbue membership. Prices set by the manufacturer.
- Licensed physician consultations & monitoring
- Dosage adjustments & prescription renewals
- Medication shipped direct from LillyDirect
- No contracts — cancel anytime
Medication price scales by dose (see table above). Membership stays a flat $29/month.
Get Started with Zepbound® VialsZepbound® from $299/month (up to $449 at higher doses) through LillyDirect delivers the highest average weight loss of any FDA-approved medication — at a price comparable to premium compounded tirzepatide programs.
Frequently Asked Questions
Ready to get started?
Begin your weight loss journey today with Zepbound® Vials. Our providers are ready to support you.